| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 11-12-25 18:45 | FC Midtjylland | KRC Genk | 1:0 |
| 11-12-25 18:45 | PFC Ludogorets Razgrad | PAOK Saloniki | 3:3 |
| 11-12-25 18:45 | FC Utrecht | Nottingham Forest | 1:2 |
| 11-12-25 18:45 | Ferencvárosi TC | Glasgow Rangers | 2:1 |
| 11-12-25 18:45 | Young Boys Bern | OSC Lille | 1:0 |
| 11-12-25 18:45 | VfB Stuttgart | Maccabi Tel Aviv | 4:1 |
| 11-12-25 18:45 | Dinamo Zagreb | Real Betis Sevilla | 1:3 |
| 11-12-25 18:45 | SK Sturm Graz | Roter Stern Belgrad | 0:1 |
| 11-12-25 18:45 | OGC Nice | Sporting Braga | 0:1 |
| 11-12-25 21:00 | FC Porto | Malmö FF | 2:1 |
| 11-12-25 21:00 | FC Basel | Aston Villa | 1:2 |
| 11-12-25 21:00 | Olympique Lyon | Go Ahead Eagles Deventer | 2:1 |
| 11-12-25 21:00 | Panathinaikos Athen | Viktoria Pilsen | 0:0 |
| 11-12-25 21:00 | SC Freiburg | FC Red Bull Salzburg | 1:0 |
| 11-12-25 21:00 | FCSB Bukarest | Feyenoord Rotterdam | 4:3 |
| 11-12-25 21:00 | Celta Vigo | FC Bologna | 1:2 |
| 11-12-25 21:00 | Celtic Glasgow | AS Rom | 0:3 |
| 11-12-25 21:00 | Brann Bergen | Fenerbahce Istanbul | 0:4 |