| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 23-10-25 18:45 | KRC Genk | Real Betis Sevilla | 0:0 |
| 23-10-25 18:45 | FC Red Bull Salzburg | Ferencvárosi TC | 2:3 |
| 23-10-25 18:45 | Brann Bergen | Glasgow Rangers | 3:0 |
| 23-10-25 18:45 | Sporting Braga | Roter Stern Belgrad | 2:0 |
| 23-10-25 18:45 | Olympique Lyon | FC Basel | 2:0 |
| 23-10-25 18:45 | Go Ahead Eagles Deventer | Aston Villa | 2:1 |
| 23-10-25 18:45 | FCSB Bukarest | FC Bologna | 1:2 |
| 23-10-25 18:45 | Fenerbahce Istanbul | VfB Stuttgart | 1:0 |
| 23-10-25 21:00 | Feyenoord Rotterdam | Panathinaikos Athen | 3:1 |
| 23-10-25 21:00 | Maccabi Tel Aviv | FC Midtjylland | 0:3 |
| 23-10-25 21:00 | OSC Lille | PAOK Saloniki | 3:4 |
| 23-10-25 21:00 | Celtic Glasgow | SK Sturm Graz | 2:1 |
| 23-10-25 21:00 | Malmö FF | Dinamo Zagreb | 1:1 |
| 23-10-25 21:00 | SC Freiburg | FC Utrecht | 2:0 |
| 23-10-25 21:00 | Nottingham Forest | FC Porto | 2:0 |
| 23-10-25 21:00 | Young Boys Bern | PFC Ludogorets Razgrad | 3:2 |
| 23-10-25 21:00 | AS Rom | Viktoria Pilsen | 1:2 |
| 23-10-25 21:00 | Celta Vigo | OGC Nice | 2:1 |